Introduction: Sub-clinical hypothyroidism (SCH) can be defined as normal Free Thyroxine (FT4) and Free Tri-iodothyronine (FT3) concentrations and high serum TSH concentration associated with few or no signs and symptoms of hypothyroidism. The level of lipid profile and lipoprotein is higher in sub-clinical hypothyroidism which was associated with cardiovascular disease in addition also increase the incidence of coronary risk factor, so newly diagnosed SCH subjects must monitor their lipid profile to prevent cardiovascular manifestation. Material and Methods: This paper is a cross-sectional study of 800 subjects (including rural and urban areas) of Amber Tehsil in Jaipur District. The blood samples (lipid profile and lipoprotein) were analyzed at the National Institute of Medical Sciences and Research, Jaipur. Result: Using a T-test it was found that total Cholesterol (TC) and Low-Density Lipoprotein Cholesterol (LDL-C) of rural and urban populations were significantly higher in the SCH group as compared to the Euthyroidism (EuT) group (p<0.05). Conclusion: Serum total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) were significantly higher in SCH subjects as compared to subjects with normal thyroid function in urban as well as rural populations. The difference in triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and very low-density lipoprotein cholesterol (VLDL-C) in SCH subjects and subjects with normal thyroid function was not significant.

Introduction: Sub-clinical hypothyroidism (SCH) can be defined as normal Free Thyroxine (FT4) and Free Tri-iodothyronine (FT3) concentrations and high serum TSH concentration associated with few or no signs and symptoms of hypothyroidism. The level of lipid profile and lipoprotein is higher in sub-clinical hypothyroidism which was associated with cardiovascular disease in addition also increase the incidence of coronary risk factor, so newly diagnosed SCH subjects must monitor their lipid profile to prevent cardiovascular manifestation. Material and Methods: This paper is a cross-sectional study of 800 subjects (including rural and urban areas) of Amber Tehsil in Jaipur District. The blood samples (lipid profile and lipoprotein) were analyzed at the National Institute of Medical Sciences and Research, Jaipur. Result: Using a T-test it was found that total Cholesterol (TC) and Low-Density Lipoprotein Cholesterol (LDL-C) of rural and urban populations were significantly higher in the SCH group as compared to the Euthyroidism (EuT) group (p<0.05). Conclusion: Serum total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) were significantly higher in SCH subjects as compared to subjects with normal thyroid function in urban as well as rural populations. The difference in triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and very low-density lipoprotein cholesterol (VLDL-C) in SCH subjects and subjects with normal thyroid function was not significant.