Introduction: Urolithiasis denotes formation of stone in the urinary tract; it may be in the kidney, ureter or in the bladder. Urinary stones are considered as a very common cause of morbidity affecting about 5-15% of population. Apart from conservative treatment, shock wave lithotripsy and ureteroscopy are commonly practiced in conventional medicine, in cases of calculi, but these interventions are expensive for the common people and may lead to complications. Here is a case of ureterolithiasis or ureteric calculus successfully treated with homoeopathic organ remedy Hydrangea arborescens 30. Case Profile: A 59 year old female presented with intense pain in loins, especially on the right side and increased frequency of urine. Ultrasonographic report confirmed a solitary stone of 8 mm in the right vesico-ureteric junction. Although advised for surgical intervention, she opted for homoeopathic treatment. She was prescribed with Hydrangea arborescens 30 as an organ remedy, on the basis of certain particular symptoms and pathology pertaining to this medicine, after which she was relieved from the intense pain. Numerical Rating Scale (NRS) score showed significant improvement and ultrasonography after 3 months of treatment showed no stone. Most importantly, although Hydrangea arborescens is popularly known as a left-sided medicine for ureteric colic and stone, and the patient had right-sided ureteric stone, yet its local affinity for ureters and pathological affinity for ureteric stones guided its prescription and ultimately, yielded the desired result. Conclusion: Besides the constitutional or individualized treatment, correct homoeopathic organ specific medicines selected on the basis of important particular symptoms can also be effective. As per the homoeopathic literature, Hydrangea arborescens has profound action on the ureters particularly ureteric stones and this case report has justified the fact. However, randomized control trials on action of Hydrangea arborescens in cases of urinary stones are suggested. Key words - Homoeopathy, Ureterolithiasis, Organ remedies, Hydrangea arborescens.