Aim: This study determine various treatment and segregation methods practiced in disposing HCW in Nembe LGA.A census sampling technique was adopted to select the participants for this study. Results: The study consist of 27 males and 23 female staff subjects randomly interviewed in one hospital and 24 health centres. Findings from this study indicate that >40yrs make up the highest proportion of respondents while those between the ages of 20-29yrs are the least among the recruited respondents. The level of education among staff with ND and HND was far higher compared to staff with Msc degree and school cert. The study also reveal that the hospital visited has waste disposal containers around its premises. However containers were not observed in some health centres during the study period. The autoclave and microwave was effectively used in the hospital as a means of disinfecting health care instrument after use (44%) as against health centres of none but 12% of chemical use as means of disinfection. Also, revelation from this study indicate thathealth care wastes generated at the Nembe General Hospital are moderately managed. The study further reveal that both staff in the various facilities do regularly transfer sharp objects that have been used to the LGA headquarter for proper incineration. Conclusion: Most health care centres dispose their HCW into the river, with bushy surrounding without regular fumigation of its environment. This has created an avenue for mosquitoes forming breeding sites leading to their increase in number with the possibilities of spreading malaria rapidly to both staff, patients and other subjects..