Stroke is a functional brain disorder that occurs suddenly with focal or global clinical signs that last more than 24 hours without signs of non-vascular causes, including signs of subarachnoid hemorrhage, intracerebral hemorrhage, ischemia, or cerebral infarction. The aim of this research is to analyze the effectiveness of proprioceptive Neuromuscular Facilitation (PNF) and Strengthening Exercises to Increase Hand Muscle Strength in Stroke Patients at the Farmers and Fishermen's Hospital, Boalemo Regency. Quaisy experimental research designed two groups pre-test and post-test design. The sample was 30 people, sampling used the purposive sampling technique. Analysis was carried out using the paired t-test and independent t-test. The results of the research were that there was a difference in Hand Muscle Strength values between those given Proprietary Neuromuscular Facilitation (PNF) with Strengthening Exercise with (p-value 0.039). The conclusion of this research is the provision of Proprioceptive Neuromuscular Facilitation (PNF). better in increasing hand muscle strength values compared to the Strengthening Exercise. It is recommended that the Farmers and Fishermen's Hospital of Boalemo Regency, in providing healing to stroke patients, apply Proprioceptive Neuromuscular Facilitation and Strengthening Exercise therapy as a complementary therapy for healing stroke patients.