This software contains two data processing workflows. The first one is applied for the suspect listgeneration of PFAS from publically available resources (Suspect list generation workflows). The second workflow uses the created suspect list and input measurement data for theidentification of PFAS (PFlow, identification workflow). The suspect list generation workflow was developed for generating suspect lists for PFAS (Per- andpolyfluoroalkyl substances). It addresses the challenge of non-uniform information across existingsuspect lists and incorporates isotopologues into the suspect list for direct use in isotopeanalysis. Users can choose to include these isotopologues in the final suspect list during theconfiguration step. Pflow is an automated data processing workflow designed for processing DI-UHRMS data from FT-ICRMS, implemented in KNIME. It integrates R scripts and native KNIME nodes to perform molecular massmatching and validation using heavy isotopes (C, S, O, Cl, Br, Si).