Abstract:Aim: The aim of the present study was to identify the etiology, assess and compare the clinical features,histomorphological parameters and outcomes of patients with Crescentic glomerulonephritis (CrGN).Methods: This observational study was conducted in the Department of Nephrology, Patna Medical Collegeand Hospital, Patna, Bihar, India for a period of 2 years. Fifty biopsy proven crescentic glomerulonephritispatients with variable presentation were analysed in this study. Crescentic glomerulonephritis was defined bycrescent formation over 50% sampled glomeruli in biopsy specimen.Results: Immune-complex glomerulonephritis (ICGN) was the most common etiology (n = 40; 80%) followedby pauci-immune glomerulonephritis (PauciGN; n = 8; 16%) and anti-glomerular basement membrane disease(n = 2; 4%). The most common etiology of ICGN was IgA nephropathy (n = 13; 26%) followed by lupusnephritis (n = 10; 20%) and post-infectious glomerulonephritis (PIGN) (n = 10; 20%).There was no difference inthe clinical, biochemical and histopathological parameters between these categories.Conclusion: Immune-complex glomerulonephritis is the most common cause of CrGN in this part of thecountry with IgA nephropathy being the predominant disease. The clinical presentation is marked by severerenal failure at presentation and comparatively lesser response rates, higher mortality and progression to ESRDin spite of strict adherence to standard immunosuppressive therapy.

Abstract:Aim: The aim of the present study was to identify the etiology, assess and compare the clinical features,histomorphological parameters and outcomes of patients with Crescentic glomerulonephritis (CrGN).Methods: This observational study was conducted in the Department of Nephrology, Patna Medical Collegeand Hospital, Patna, Bihar, India for a period of 2 years. Fifty biopsy proven crescentic glomerulonephritispatients with variable presentation were analysed in this study. Crescentic glomerulonephritis was defined bycrescent formation over 50% sampled glomeruli in biopsy specimen.Results: Immune-complex glomerulonephritis (ICGN) was the most common etiology (n = 40; 80%) followedby pauci-immune glomerulonephritis (PauciGN; n = 8; 16%) and anti-glomerular basement membrane disease(n = 2; 4%). The most common etiology of ICGN was IgA nephropathy (n = 13; 26%) followed by lupusnephritis (n = 10; 20%) and post-infectious glomerulonephritis (PIGN) (n = 10; 20%).There was no difference inthe clinical, biochemical and histopathological parameters between these categories.Conclusion: Immune-complex glomerulonephritis is the most common cause of CrGN in this part of thecountry with IgA nephropathy being the predominant disease. The clinical presentation is marked by severerenal failure at presentation and comparatively lesser response rates, higher mortality and progression to ESRDin spite of strict adherence to standard immunosuppressive therapy.