AbstractAim: This study was done to study the serum sodium levels in chronic liver disease (CLD) patients andestablish its association with the severity of disease in such patients.Material & Methods: An observational cross-sectional study with 200 cases of chronic liver disease was donein the Department of General Medicine for 2 years.Results: All patients had abdominal distension. It was observed that patients from group A had jaundice(p<0.05) and altered sensorium (p<0.001) significantly more commonly as compared to those from group B andC. Alcohol consumption was reported by 88.5% of the patients. Serum sodium levels were not significantlyassociated with alcohol consumption. Among all examination findings, icterus (p<0.05) and clubbing (p<0.01)were found to be significantly more common among patients from group A, as compared to patients from groupB or C. Pallor, pedal edema, signs of liver cell failure and organomegaly were not significantly associated withserum sodium levels in our study population. Portal hypertension was observed in 85.5%, hepaticencephalopathy in 23.5%, hepatorenal syndrome in 21.5%, spontaneous bacterial peritonitis in 4.5% andcoagulopathy in 18%. Of these, hepatic encephalopathy (p<0.01), hepatorenal syndrome (p<0.01) andcoagulopathy (p<0.01) were found to occur significantly more common among patients from group A, ascompared to those in patients from group B or C. We observed that mean direct bilirubin, alanine transaminase,aspartate transaminase and alkaline phosphatase were significantly higher among group A patients as comparedto those from group B or C respectively. We observed that mean MELD score was significantly higher amonggroup A patients as compared to those with group B and group C. We also observed that mean Child Pugh scorewas significantly higher among group A patients as compared to those with group B and group C.Conclusion: Patients with lower serum salt levels had a substantially higher MELD score and CPS. Low bloodsodium levels were linked to more severe liver disease, greater complications, and increased death. As a result,we urge that serum salt levels be checked on a frequent basis in patients with chronic liver disease.

AbstractAim: This study was done to study the serum sodium levels in chronic liver disease (CLD) patients andestablish its association with the severity of disease in such patients.Material & Methods: An observational cross-sectional study with 200 cases of chronic liver disease was donein the Department of General Medicine for 2 years.Results: All patients had abdominal distension. It was observed that patients from group A had jaundice(p<0.05) and altered sensorium (p<0.001) significantly more commonly as compared to those from group B andC. Alcohol consumption was reported by 88.5% of the patients. Serum sodium levels were not significantlyassociated with alcohol consumption. Among all examination findings, icterus (p<0.05) and clubbing (p<0.01)were found to be significantly more common among patients from group A, as compared to patients from groupB or C. Pallor, pedal edema, signs of liver cell failure and organomegaly were not significantly associated withserum sodium levels in our study population. Portal hypertension was observed in 85.5%, hepaticencephalopathy in 23.5%, hepatorenal syndrome in 21.5%, spontaneous bacterial peritonitis in 4.5% andcoagulopathy in 18%. Of these, hepatic encephalopathy (p<0.01), hepatorenal syndrome (p<0.01) andcoagulopathy (p<0.01) were found to occur significantly more common among patients from group A, ascompared to those in patients from group B or C. We observed that mean direct bilirubin, alanine transaminase,aspartate transaminase and alkaline phosphatase were significantly higher among group A patients as comparedto those from group B or C respectively. We observed that mean MELD score was significantly higher amonggroup A patients as compared to those with group B and group C. We also observed that mean Child Pugh scorewas significantly higher among group A patients as compared to those with group B and group C.Conclusion: Patients with lower serum salt levels had a substantially higher MELD score and CPS. Low bloodsodium levels were linked to more severe liver disease, greater complications, and increased death. As a result,we urge that serum salt levels be checked on a frequent basis in patients with chronic liver disease.