Insulin, in addition to being a pivotal metabolic hormone, plays a significant role in intracellular calcium homeostasis. Ca2+-ATPase, an integral membrane protein found in the plasmalemma or organellar membrane of all cells, responsible for the maintenance of intracellular calcium homeostasis. It has been extensively studied with respect to its structure and mechanism of action, and more recently to gene expression. Though the concept of insulin mediated calcium transport is not new, an involvement of insulin in calcium homeostasis is still under discussion. Therefore, the analysis of the transporter responses to insulin would offer mechanistic understanding of calcium specific transporters to insulin and how cellular processes respond to insulin signaling in the intracellular milieu.