Background: Periodontitis typically affects the supporting tissues of the teeth, and potentially could produce impacts on individual?s oral health-related quality of life (OHRQoL) Objective: To assess the impact of periodontal health status on quality of life among subjects diagnosed with periodontal disease in a university setting in Riyadh, Saudi Arabia. Material and methods: The study included asimple random sample of 25 adults referred to the periodontal clinics at the College of Dentistry, King Saud University. The Arabic short-form version of the oral health impact profile (OHIP-14) was used to assess oral health-related quality of life. Subjects enrolled in this cross-sectional study were requested to fill the OHIP-14questionnaire and underwent a comprehensive periodontal clinical examination. Please write briefly the clinical measurements taken. Clinical examination was conducted. The oral hygiene and periodontal status of all teeth except third molars were recorded. Probing pocket depth (PPD), clinical attachment level (CAL), and bleeding on probing (BOP) were assessed at six points per tooth. Results: the impact of periodontal disease on the patient?s quality of life was statistically significant in two domains, physical pain (P value .004) and psychological disability (P value .001). The severity of periodontal disease did not show a negative impact on functional limitation. Conclusion: By using the Arabic version of the OHIP -14 index, periodontal disease had a negative impact on quality of life.