Kaposi?s Sarcoma (KS) is a low-grade vascular tumor that derived from lymphatic endothelial cells infected with type 8 of human herpes virus (HHV8) also known as Kaposi Sarcoma associated herpesvirus (KSHV). Iatrogenic form of KS is most often detected in patients after kidney transplantation which reflects the higher frequency in this population. KSis most notable for its cutaneous involvement, characterized by dermal purplish, reddish blue, or dark black macules, plaques, and nodules. Lymph node enlargement and visceral localization are other clinical manifestation of KS. Visceral involvement occurs in 25 to 30 percent of patients with kidney transplants and in 50 percent of those with liver or heart transplants. We present a 46-year-old man undergoing dialysis due to lupus nephritis, with multiple lymph nodes who had biopsy-proven KS.