This article provides information on the fact that the peoples of Central Asia established international relations as the first state associations and carried out exchanges of embassies based on information written by historians of that time, including Ctesius Knidsky, Herodotus and other sources. In particular, there is information about the emergence of diplomatic relations in "Avesta" as early as the first half of the first millennium BC. Regarding the relations of the peoples of Central Asia with Media and Assyria and then the exchange of embassies with the Achaemenid Empire as a result of the entry of the Achaemenids from the second half of the 6th century BC and its results; In 330-327 BC, Alexander the Great's invasion campaigns to Central Asia and diplomatic relations during this period are discussed.