Introduction: Endometrial pathologies refer to abnormalities affecting the uterine lining, and various sampling techniques are used to diagnose these conditions. Pipelle biopsy is a minimally invasive procedure, while hysterectomy and dilatation and curettage (D&C) are more invasive approaches. Comparing the findings of pipelle biopsy with histopathology from hysterectomy or D&C can provide valuable information for managing endometrial pathologies. Objective: The objective of this study was to compare pipelle biopsy reports with hysterectomy/D&C histopathology reports and determine the sensitivity and specificity of pipelle curette for endometrial pathologies. Material and Methods: The study was a prospective interventional study conducted at the Department of Obstetrics and Gynecology, Kamla Raja Hospital, Gwalior. The sample size included 100 women above 30 years or women presenting with postmenopausal bleeding. Pipelle biopsy was performed, and the samples were sent for histopathology. Statistical analysis was done using SPSS software. Results: The study compared the findings of pipelle biopsy with hysterectomy/D&C and found that the frequency of secretory endometrium was similar in both procedures. However, approximately 15% of pipelle biopsy samples were inadequate. False positive findings with pipelle biopsy included squamous metaplasia, squamous cell carcinoma (SCC), and non-keratinizing squamous cell carcinoma (NKSCC). False negative findings included adenocarcinoma, senile endometrium, and endometritis. Conclusion: The study highlights the limitations and potential pitfalls of pipelle biopsy compared to hysterectomy/D&C. While pipelle biopsy can provide valuable information for certain conditions, it may miss or misdiagnose others. Clinicians should be aware of the potential for false negative and false positive results when interpreting pipelle biopsy findings and may need to use additional diagnostic tools or procedures for a more comprehensive evaluation of uterine pathology.

Introduction: Endometrial pathologies refer to abnormalities affecting the uterine lining, and various sampling techniques are used to diagnose these conditions. Pipelle biopsy is a minimally invasive procedure, while hysterectomy and dilatation and curettage (D&C) are more invasive approaches. Comparing the findings of pipelle biopsy with histopathology from hysterectomy or D&C can provide valuable information for managing endometrial pathologies. Objective: The objective of this study was to compare pipelle biopsy reports with hysterectomy/D&C histopathology reports and determine the sensitivity and specificity of pipelle curette for endometrial pathologies. Material and Methods: The study was a prospective interventional study conducted at the Department of Obstetrics and Gynecology, Kamla Raja Hospital, Gwalior. The sample size included 100 women above 30 years or women presenting with postmenopausal bleeding. Pipelle biopsy was performed, and the samples were sent for histopathology. Statistical analysis was done using SPSS software. Results: The study compared the findings of pipelle biopsy with hysterectomy/D&C and found that the frequency of secretory endometrium was similar in both procedures. However, approximately 15% of pipelle biopsy samples were inadequate. False positive findings with pipelle biopsy included squamous metaplasia, squamous cell carcinoma (SCC), and non-keratinizing squamous cell carcinoma (NKSCC). False negative findings included adenocarcinoma, senile endometrium, and endometritis. Conclusion: The study highlights the limitations and potential pitfalls of pipelle biopsy compared to hysterectomy/D&C. While pipelle biopsy can provide valuable information for certain conditions, it may miss or misdiagnose others. Clinicians should be aware of the potential for false negative and false positive results when interpreting pipelle biopsy findings and may need to use additional diagnostic tools or procedures for a more comprehensive evaluation of uterine pathology.