Background: Vitiligo is alternatively known as leukoderma which is an autoimmune skin condition that arrives due to expression of low melanin pigment. Vitiligo is although is not very uncommonly seen, difficulties exist for its successful treatment. Objective: Treatment of Vitiligo with homeopathic medication. Case Reports: A female 7 years old child with Vitiligo around her both the eyes was considered as the subject for the present study. She was treated with some of homoeopathic medicines such as Arsenicum sulfuratum flavum-6X, Hydrocotyle-Ø and Psoralea cor- Ø were prescribed as empirical formulations; albeit a successful result was not achieved. Based on her the totality of symptom, a constitutional medicine Calc. carb- 0/1 to 0/8, was able to fully cure the Vitiligo spots within 4 months. Conclusions: In a 7 years girl with Vitiligo treated with individualized homeopathy, the cure was achieved. It is believed that homeopathy may be effective in treatment of Vitiligo with careful selection of medicine(s) as per the totality of the symptoms of the patient. Key words: Vitiligo, Homoeopathy, Calc. carb, Constitutional medicine