This Multi-annual Action Plan proposes a series of framework actions to guide the implementation of the Science Europe Strategy Plan 2021–2026 in line with the association's updated vision, mission, values, and strategic priorities. It also describes mechanisms through which Science Europe's objectives will be achieved such as the various Working Group that will engage the membership, facilitate exchange, and build expertise on a variety of topics. Update: This Multi-Annual Action Plan was updated in June 2024 to include several new activities that emerged during the first years of the plan, such as the need to address the emergence of artificial intelligence in research.