Introduction: Benign prostatic enlargement is one of the most prevalent ageing related derangements in men and has significant impact on quality of life. This study was designed to find the association of Vitamin-D levels and prostatomegaly grade in patients of BPH. Material and Methods: After Ethical Committee approval, blood sample was collected from 60 BPH patients. Vitamin-D level was measured by Chemilunimiscence method in fully automated Advia-centaur analyser. Results were analysed in relation to the prostatomegaly grades in patients of BPH using students ‘t’ test. Vitamin-D level < 20 ng/ml was considered deficient. Result: Serum Vitamin D level was less in patients with Grade 3 prostatomegaly (16.65 ± 2.914) than patients with Grade 1 (20.438 ± 3.785) and Grade 2 ( 19.645 ± 3.853) prostatomegaly and found statistically significant. Conclusion: Our study showed significantly lower levels of Vitamin-D (p value <0.001) with higher prostatomegaly grade in males with BPH. Thus Vitamin-D levels may have a significant role in the etiopathogenesis of BPH & severity of symptoms. Vitamin D deficiency may be used as a therapeutic target for preventing and treating BPH.

Introduction: Benign prostatic enlargement is one of the most prevalent ageing related derangements in men and has significant impact on quality of life. This study was designed to find the association of Vitamin-D levels and prostatomegaly grade in patients of BPH. Material and Methods: After Ethical Committee approval, blood sample was collected from 60 BPH patients. Vitamin-D level was measured by Chemilunimiscence method in fully automated Advia-centaur analyser. Results were analysed in relation to the prostatomegaly grades in patients of BPH using students ‘t’ test. Vitamin-D level < 20 ng/ml was considered deficient. Result: Serum Vitamin D level was less in patients with Grade 3 prostatomegaly (16.65 ± 2.914) than patients with Grade 1 (20.438 ± 3.785) and Grade 2 ( 19.645 ± 3.853) prostatomegaly and found statistically significant. Conclusion: Our study showed significantly lower levels of Vitamin-D (p value <0.001) with higher prostatomegaly grade in males with BPH. Thus Vitamin-D levels may have a significant role in the etiopathogenesis of BPH & severity of symptoms. Vitamin D deficiency may be used as a therapeutic target for preventing and treating BPH.