This review provides a depth information state of art of approach to advance drug delivery through Nano emulsion systems and nanogels for topical application. Nano emulsions and Nanogels mainly constitute of cutting-edge technology in drug delivery offering creative and innovative solutions to address limitations of conventional methods. This review provides full information of nanotechnology covering formulation, preparation technique, properties and advantages. Nano emulsion express superior stability and resistance to aggregation, making them ideal for various pharma companies, including biotechnology, medication therapy, cosmetics and diagnostics. In parallel nanogels, cross linked polymers networks, have emerged and promising carriers for both hydrophilic and hydrophobic chemical agents. This review mainly explains the diverse features of nanogels, including dimensions, shape, porosity and amphiphilicity, degradability which is able to tailored to meet specific drug development and information of all Nano emulsion and nanogels used in topical drug delivery.