The novel shape and adaptability of cubosomes, which are nanostructured lipid-based particles, have made them an attractive candidate for use as drug delivery vehicles. This abstract provides a concise overview of cubosomes, highlighting their structural features, formation mechanisms, and applications in the biomedical and pharmaceutical fields.Cubosomes are self-assembled lipid nanoparticles characterized by a bicontinuous cubic liquid crystalline structure. Formation of these structures involves the hydration of lipid mixtures, resulting in the creation of a three-dimensional network with water channels. The distinct cubic symmetry of cubosomes imparts them with advantageous properties, like high surface area, stability, and controlled release capabilities. In the context of drug delivery, cubosomes offer an ideal platform for encapsulating hydrophobic and hydrophilic drugs, allowing for improved solubility and bioavailability. Their nanoscale size enables efficient transport through biological barriers, leading to enhanced therapeutic outcomes.