After the conquest of Istanbul in 1453, most Byzantine structures were converted into mosques within the scope of the Deconstruction policy, but there are also church structures still actively used by Orthodox and Catholic communities. In this study, where the establishment processes of these historical structures serving two different civilizations and two different religions are examined, the social aspect of monastic life along with the architectural space layouts and historical interactions have been determined. Since the units belonging to the monastic organizations located within the boundaries of Istanbul disappeared over time and only the church structures have survived to the present the study examined the history and architectural features of Bodrum Mesih Pasha Mosque (Myrelaion Monastery), an analysis of the old restoration works, as well as its current state.