Data related to the article Posttreatment with PaPE-1 Protects from Aβ-Induced Neurodegeneration Through Inhibiting the Expression of Alzheimer's Disease-Related Genes and Apoptosis Process That Involves Enhanced DNA Methylation of Specific Genes. These are biochemical, molecular and microscopic data. We aimed to verify the neuroprotective capacity of PaPE-1 against amyloid beta (Aβ)-induced toxicity. Fig 1 – the presence of amyloid beta in cellular cultures; Fig 2 – the effects of apoptosis inhibitors on amyloid beta-induced caspase-3 activity; Fig 3 – the effects of amyloid beta and PaPE-1 on caspase -3, -8, and -9 activities; Fig 4 – effects of amyloid beta and PaPE-1 on Calcein AM and Hoechst 33342 staining; Fig 5 – effects of amyloid beta and PaPE-1 on expression of apoptosis related factors; Fig 6 – effects of amyloid beta and PaPE-1 on methylation of specific genes; Fig 7 – effects of amyloid beta and PaPE-1 on the degree of neurodegeneration; Fig 8 - effects of amyloid beta and PaPE-1 on the membrane stain; Fig 9 - effects of amyloid beta and PaPE-1 on the expression of Alzheimer’s disease-related genes.