Background: Tapentadol is a relatively new analgesic. The comparison between nasal versus oral formulations was done for their various effects in the perioperative period. Setting: A study conducted in a tertiary care hospital. Materials and Methods: Sixty adults, of the American Society of Anaesthesiologists Classes I or II of either sex and age 20–60 years of age undergoing elective laparoscopic cholecystectomies done under general anaesthesia of minimum 90 minutes to less than or equal to 120 minutes duration were divided into 2 groups of 30 each by computerized random allotment (Group –N: Nasal Tapentadol, Group –T: Oral Tapentadol). Group N received two puffs of nasal Tapentadol ( Nearly 25mg per puff), 5mins before induction of anaesthesia. Group T received one oral Tapentadol tablet 100mg, 60 minutes before induction of anaesthesia. Statistics: Randomized Control trial, Proportion tests, Correlation, ANOVA, Kruskal Walis test, Regression analysis, Paired t-test, Chi-square test, F test, and, any other analysis found suitable, P-value for analytical purposes: 0.05 [95% Confidence Interval], Software for Statistical Analysis: MS-Excel/ STATA 14 were used for statistics. Results: Nasal Tapentadol group patients had significantly better analgesia 3 h postoperatively than the oral tapentadol group. Conclusions: From the Result and Analysis it was concluded that nasal Tapentadol had better analgesic efficacy and hemodynamic stability as compared to oral formulations.

Background: Tapentadol is a relatively new analgesic. The comparison between nasal versus oral formulations was done for their various effects in the perioperative period. Setting: A study conducted in a tertiary care hospital. Materials and Methods: Sixty adults, of the American Society of Anaesthesiologists Classes I or II of either sex and age 20–60 years of age undergoing elective laparoscopic cholecystectomies done under general anaesthesia of minimum 90 minutes to less than or equal to 120 minutes duration were divided into 2 groups of 30 each by computerized random allotment (Group –N: Nasal Tapentadol, Group –T: Oral Tapentadol). Group N received two puffs of nasal Tapentadol ( Nearly 25mg per puff), 5mins before induction of anaesthesia. Group T received one oral Tapentadol tablet 100mg, 60 minutes before induction of anaesthesia. Statistics: Randomized Control trial, Proportion tests, Correlation, ANOVA, Kruskal Walis test, Regression analysis, Paired t-test, Chi-square test, F test, and, any other analysis found suitable, P-value for analytical purposes: 0.05 [95% Confidence Interval], Software for Statistical Analysis: MS-Excel/ STATA 14 were used for statistics. Results: Nasal Tapentadol group patients had significantly better analgesia 3 h postoperatively than the oral tapentadol group. Conclusions: From the Result and Analysis it was concluded that nasal Tapentadol had better analgesic efficacy and hemodynamic stability as compared to oral formulations.