Background: Transdermal drug delivery system (TDDS) was designed for the sustain release of content and for improving bioavilability of drug which improves patient compliance. There are various types of transdermal patches in which matrix dispersion type systems disperse the drug in the solvent along with the polymers and solvent is allowed to evaporate forming a homogeneous drug‑polymer matrix. To design and formulate TDDS of topiramate (TPM) and to evaluate their extended release in vitro and ex vivo was the main objective of present study. Materials and Methods: The Trandermal patches of topiramate (TPM) prepared by solvent casting method using a combination of ethylcellulose, polyvinylpyrolidone (PVP), eudragit L 100, calcium monophosphide (CAP), carbopol in various ratios using polyethylene glycol (PG) as a plasticizers and oleic acid, Tween 80 as a permeation enhancers were studied. Results: The physicochemical compatibility of the drug and the polymers was studied by Fourier transform infrared spectroscopy. The results obtained showed no physical‑chemical incompatibility between the drug and the polymers. The patches were further subjected to various physical evaluations along with the exvivo permeation studies using pig ear skin. Conclusions: On the basis of results obtained from the physical evaluation and ex vivo studies the patches containing the polymers, that is, Eudragit L 100 and polyvinylpyrrolidone, with oleic acid as the penetration enhancer were considered as the best formulations for the transdermal delivery of TPM.