Background – Gall stone disease a common clinical condition ,mostly affecting the females. Its incidence is increasing in the recent times , owing to various risk factors.Previous literature have reported metabolic syndrome to be present in patients diagnosed with gall stone disease. Aims & Objectives- To assess the association between the presence of gallstone disease and metabolic Syndrome. Material & Methods- This prospective, observational study recruited patients (n=60, age range 20-65 yrs) having cholelithiasis who were admitted in the Department of Surgery , of our tertiary care Hospital from January 2023 to September 2023. Normal healthy persons (n=60, age range 20-65 yrs) with no evidence of cholelithiasis on ultrasonography were taken as controls.CBC, fasting blood sugar, serum lipid profile,ultrasonography was conducted. Metabolic syndrome was defined by adult treatment panel III (ATP III) criteria. Results – Both the groups were comparable with respect to age and gender & with no statistically significant difference. In the Case group, 24 (40%), while in control group 11(17% ) of the study participants fulfilled the criteria for metabolic syndrome which showed statistically significant difference (p<0.05). Waist circumference , diabetes mellitus , low serum high density lipoprotein were statistically significantly higher in Case group as compared to control group . Hypertension & serum triglycerides levels were also elevated in case group with no statistically significant difference. A positive association was found between waist circumference , DM & low serum high density lipoprotein & gall stone disease which was statistically significant(p<0.05). Conclusion – Metabolic syndrome was statistically significantly associated with gall stone disease & can be used to predict the risk . Increased waist circumference , diabetes & low serum high density lipoprotein are the noted findings in Gall stone disease & should be management to prevent any complications. Key words – Metabolic syndrome ,Gall stone disease, dyslipidemia, insulin resistance ,diabetes mellitus

Background – Gall stone disease a common clinical condition ,mostly affecting the females. Its incidence is increasing in the recent times , owing to various risk factors.Previous literature have reported metabolic syndrome to be present in patients diagnosed with gall stone disease. Aims & Objectives- To assess the association between the presence of gallstone disease and metabolic Syndrome. Material & Methods- This prospective, observational study recruited patients (n=60, age range 20-65 yrs) having cholelithiasis who were admitted in the Department of Surgery , of our tertiary care Hospital from January 2023 to September 2023. Normal healthy persons (n=60, age range 20-65 yrs) with no evidence of cholelithiasis on ultrasonography were taken as controls.CBC, fasting blood sugar, serum lipid profile,ultrasonography was conducted. Metabolic syndrome was defined by adult treatment panel III (ATP III) criteria. Results – Both the groups were comparable with respect to age and gender & with no statistically significant difference. In the Case group, 24 (40%), while in control group 11(17% ) of the study participants fulfilled the criteria for metabolic syndrome which showed statistically significant difference (p<0.05). Waist circumference , diabetes mellitus , low serum high density lipoprotein were statistically significantly higher in Case group as compared to control group . Hypertension & serum triglycerides levels were also elevated in case group with no statistically significant difference. A positive association was found between waist circumference , DM & low serum high density lipoprotein & gall stone disease which was statistically significant(p<0.05). Conclusion – Metabolic syndrome was statistically significantly associated with gall stone disease & can be used to predict the risk . Increased waist circumference , diabetes & low serum high density lipoprotein are the noted findings in Gall stone disease & should be management to prevent any complications. Key words – Metabolic syndrome ,Gall stone disease, dyslipidemia, insulin resistance ,diabetes mellitus