The primary environmental health threat in the WHO European Region is air pollution, impacting the daily health and well-being of its citizens significantly. To effectively understand the impact, and dynamics of air quality a detailed investigation of different environmental, weather, and land cover indices is appropriate. To this end, this paper introduces three European cities’ spatiotemporal datasets, customized for air pollution monitoring at a regional level. The datasets are composed of major air quality, weather measurements and land use information. The duration is approximately from 2020 to 2023 with an hourly temporal resolution and a spatial resolution of 0.005◦. The temporal and spatiotemporal datasets are publicly released aiming to provide a solid foundation for researchers, analysts, and practitioners to conduct in-depth analyses of air pollution dynamics.