Background: Psoriasis is a chronically relapsing autoimmune skin disorder. It is characterised by complex alterations in epidermal growth and differentiation. Thyroid hormone plays a major role in the regulation of cell growth and differentiation. Triiodothyronine (T3) and thyroxine (T4) hormones have hyper-proliferative effect on epidermis of skin. Evidences regarding thyroid abnormalities in psoriasis are limited by less number of studies and in-conclusive outcome. Objective: To detect thyroid hormone abnormality in cases of psoriasis disease. Methods: One hundred cases of psoriasis were evaluated clinically and confirmed by histopathology. Thyroid stimulating hormone (TSH), T3 and T4 hormones were measured among cases and controls. Results: Eight percent cases of psoriasis had thyroid abnormalities as compared to four percent in control group. We did not find any significant association of thyroid disorder in cases of psoriasis as compared to control group (z value=1.191, p-value= 0.234, p-value <0.05). There was a positive trend of low TSH levels in cases of psoriasis, but it was not statistically significant (p-value=0.07).There was no statistically significant difference between levels of T3 and T4 hormone in cases and controls. Conclusion: Our study suggests that there was no statistically significant association between thyroid disorder and psoriasis disease. We did find a positive trend of low TSH levels in psoriasis disease, but not statistically significant.

Background: Psoriasis is a chronically relapsing autoimmune skin disorder. It is characterised by complex alterations in epidermal growth and differentiation. Thyroid hormone plays a major role in the regulation of cell growth and differentiation. Triiodothyronine (T3) and thyroxine (T4) hormones have hyper-proliferative effect on epidermis of skin. Evidences regarding thyroid abnormalities in psoriasis are limited by less number of studies and in-conclusive outcome. Objective: To detect thyroid hormone abnormality in cases of psoriasis disease. Methods: One hundred cases of psoriasis were evaluated clinically and confirmed by histopathology. Thyroid stimulating hormone (TSH), T3 and T4 hormones were measured among cases and controls. Results: Eight percent cases of psoriasis had thyroid abnormalities as compared to four percent in control group. We did not find any significant association of thyroid disorder in cases of psoriasis as compared to control group (z value=1.191, p-value= 0.234, p-value <0.05). There was a positive trend of low TSH levels in cases of psoriasis, but it was not statistically significant (p-value=0.07).There was no statistically significant difference between levels of T3 and T4 hormone in cases and controls. Conclusion: Our study suggests that there was no statistically significant association between thyroid disorder and psoriasis disease. We did find a positive trend of low TSH levels in psoriasis disease, but not statistically significant.