EOSC-Life, an EC-funded H2020 project that lasted from March 2019 until August 2023 (GA 824087), brought together 13 European Life Science Research Infrastructures (RIs) such as Instruct-ERIC to create an open, digital and collaborative space for data resources and data processing workflows in the European Open Science Cloud (EOSC). As one of the RIs involved in EOSC-Life, Instruct-ERIC was actively engaged in the integration of pilot structural biology projects in EOSC-Life and other activities that would help create an open digital space for the life sciences. Through that scheme, seven research pilots led by Instruct partners aimed to develop solutions for the cloudification and FAIR handling of data resources and benefited from EOSC-life financial and technical support. The most significant achievements of Instruct-ERIC in EOSC-Life are described in this paper.