Data Multi-antigen imaging data for 69 skin tissue samples (21 cutaneous T cell lymphoma (CTCL), 23 atopic dermatitis (AD), and 25 pseudolymphoma (PSO)), obtained from 27 patients (8 CTCL, 7 AD, 12 PSO) treated at the University Hospital Erlangen. Each sample contains at least 36 protein channels, each of resolution 512 X 512 pixels. The data were generated using multi-epitope ligand cartography (MELC) (https://doi.org/10.1038/nbt1250, https://doi.org/10.1007/3-540-36459-5_8). Metadata For each sample, we information on sex, age, and condition of the corresponding patient. Samples and patients are numbered as S01 through S69 and P01 through P27, respectively. Structure of the repository The file metadata.csv contains the metadata. The archive data.zip contains one directory for each sample, named with the sample numbers S01 through S69. The directories for the individual samples contain images named -.tif, where is the name of the quantified protein marker and is the name of the flourescent protein that was used for image acquisition.