Background: Diabetic Foot Ulcers (DFUs) are a common and severe complication of diabetes, requiring effective management strategies. This study aimed to compare the outcomes of Vacuum-Assisted Closure (VAC) Therapy and Collagen Granules in the treatment of DFUs. Methods: In this prospective study, 100 patients with DFUs were randomized into two groups: VAC Therapy (n=50) and Collagen Granules (n=50). We evaluated the time to complete wound healing, infection rates, and patient comfort levels. Results: The time to complete healing was significantly shorter in the VAC Therapy group (8.2 weeks, SD ± 2.1) compared to the Collagen Granules group (9.7 weeks, SD ± 2.5) with a p-value of 0.03. The infection rates were 12% for VAC Therapy and 18% for Collagen Granules, not statistically significant (p = 0.30). Patient comfort was significantly higher in the Collagen Granules group (88%) compared to the VAC Therapy group (75%, p = 0.04). Conclusion: VAC Therapy demonstrated a faster healing time for DFUs, while Collagen Granules were favored for patient comfort. The choice of treatment should consider both clinical efficacy and patient preferences. Future studies focusing on long-term outcomes and cost-effectiveness are needed.

Background: Diabetic Foot Ulcers (DFUs) are a common and severe complication of diabetes, requiring effective management strategies. This study aimed to compare the outcomes of Vacuum-Assisted Closure (VAC) Therapy and Collagen Granules in the treatment of DFUs. Methods: In this prospective study, 100 patients with DFUs were randomized into two groups: VAC Therapy (n=50) and Collagen Granules (n=50). We evaluated the time to complete wound healing, infection rates, and patient comfort levels. Results: The time to complete healing was significantly shorter in the VAC Therapy group (8.2 weeks, SD ± 2.1) compared to the Collagen Granules group (9.7 weeks, SD ± 2.5) with a p-value of 0.03. The infection rates were 12% for VAC Therapy and 18% for Collagen Granules, not statistically significant (p = 0.30). Patient comfort was significantly higher in the Collagen Granules group (88%) compared to the VAC Therapy group (75%, p = 0.04). Conclusion: VAC Therapy demonstrated a faster healing time for DFUs, while Collagen Granules were favored for patient comfort. The choice of treatment should consider both clinical efficacy and patient preferences. Future studies focusing on long-term outcomes and cost-effectiveness are needed.