The study of the genetic and biochemical basis of the problem of the formation of post-acne scar changes, as well as the establishment of significant molecular genetic and biochemical markers is almost at the very initial stage of development⁷᾿⁸᾿⁹᾿¹⁰᾿¹¹᾿¹²᾿¹³. Recently, the literature very often states the presence of a pathogenetic connection between unfavorable genotypes with the formation of an atrophic form of post-acne¹, which became the goal of our study. Of these, works devoted to assessing the significance of the 1997C/A polymorphism of the COL1A1 gene (including indirectly) in the formation of post-acne scar changes are limited to single studies¹᾿¹⁴᾿¹⁵᾿¹⁶ In addition to these, there are works devoted to the role of epigenetic factors in disruption of COL1A1 collagen synthesis and the development of scars post-acne¹⁷᾿¹⁸᾿¹⁹. At the same time, our results are consistent with the data of the above researchers