Background: Gall bladder lesions are remaining exceedingly ubiquitous and often needs surgical intervention. The histopathological patterns represent a spectrum, ranging from cholecystitis to gallbladder carcinoma. Histopathological analysis provide definitive diagnosis on resected specimen and hence ultimately help in further future management. Amongst all lesions cholecystitis with Cholelithiasis is known to produce diverse histopathological changes in the gallbladder mucosa. The present study aims to define the occurrence of various gallbladder lesions on histology. Method: This was a prospective observational study conducted in the Department of Pathology at Teaching Institute in Central India. The study period was two year, from first January 2021 to 31st December 2022. A total of 185 patients who underwent cholecystectomy at the institute were included in the study. Gross features of cholecystectomy specimens were recorded. Three sections each from the neck, body, and fundus were taken. Histopathological diagnosis was correlated with demographic data. Results: Total 185 patients were included, out of which 130 were females and 55 were males, with the mean age 45 years. 180 cases associated with different types of gall stones. The most common histopathological findings were chronic cholecystitis, observed in 164 patients i.e. 88.64% followed by adenocarcinoma of gall bladder 9 patients, 7 patients with acute cholecystitis, 3 patients having xanthogranulomatous cholecystitis. Conclusion: Diseases of the gallbladder often mandate prompt surgical intervention. Chronic cholecystitis, which is an established risk factor for gallbladder carcinoma, is one of the commonest presentations. Therefore detailed and meticulous histopathological examination remains crucial in the detection of premalignant and malignant lesions.

Background: Gall bladder lesions are remaining exceedingly ubiquitous and often needs surgical intervention. The histopathological patterns represent a spectrum, ranging from cholecystitis to gallbladder carcinoma. Histopathological analysis provide definitive diagnosis on resected specimen and hence ultimately help in further future management. Amongst all lesions cholecystitis with Cholelithiasis is known to produce diverse histopathological changes in the gallbladder mucosa. The present study aims to define the occurrence of various gallbladder lesions on histology. Method: This was a prospective observational study conducted in the Department of Pathology at Teaching Institute in Central India. The study period was two year, from first January 2021 to 31st December 2022. A total of 185 patients who underwent cholecystectomy at the institute were included in the study. Gross features of cholecystectomy specimens were recorded. Three sections each from the neck, body, and fundus were taken. Histopathological diagnosis was correlated with demographic data. Results: Total 185 patients were included, out of which 130 were females and 55 were males, with the mean age 45 years. 180 cases associated with different types of gall stones. The most common histopathological findings were chronic cholecystitis, observed in 164 patients i.e. 88.64% followed by adenocarcinoma of gall bladder 9 patients, 7 patients with acute cholecystitis, 3 patients having xanthogranulomatous cholecystitis. Conclusion: Diseases of the gallbladder often mandate prompt surgical intervention. Chronic cholecystitis, which is an established risk factor for gallbladder carcinoma, is one of the commonest presentations. Therefore detailed and meticulous histopathological examination remains crucial in the detection of premalignant and malignant lesions.