Tropic fever with multiple organ dysfunction is often seen as undifferentiated fevers with organ failure. Dengue, scrub typhus, leptospirosis, malaria, typhoid fever and some other fevers are incorporated in Tropic fever. These fevers are prevalent in tropical and subtropical regions. Symptoms of tropic fever includes sudden onset of fever, headache, chills, myalgia, transient skin rashes, conjunctival suffusion. A variety of acute insults, including sepsis, can cause progressive and potentially reversible physiologic dysfunction in two or organs or organ systems which is what is known as MODS (Multiple Organ Dysfunction Syndrome). A patient may present with overlapping symptoms due to concurrent infections with multiple etiological dysfunction can range in severity from mild to severe, and different organs may exhibit different levels of malfunction. There is no commonly accepted classification system outlines parameters of organ specific failure. To guide critical care specialists, evidence based algorithms are presented based on early empiric therapy based on clinical syndromes.