Background: Hypertension disorders represent the most common medical complication of pregnancy. Studies state that abnormal placentation and endothelial dysfunction are the key factors in the development of pre-eclampsia. Lipid levels in the early pregnancy can be a good predictor of development of preeclampsia. Dyslipidemia in early pregnancy leads to more oxidative stress by the formation of lipid peroxidases and reactive oxygen species, thus predisposing to development of pre-eclampsia. The pathological state of hypertension at the maternal period predisposing the condition of pre-eclampsia occurs due to reduced capacity of perfusion in placenta enhance the dysfunction of vascular endothelial system which arises from lesser invasion of cytotrophoblasts into the arteries of uterus. The research aims to estimate the lipid concentration in the second trimester of pregnancy for prediction of hypertension. Materials and Methods: This study was done as a prospective cohort study at antenatal clinic, department of obstetrics and gynecology at Government Mohan Kumaramangalam medical college, Salem. Pregnant women with singleton pregnancy with LMP and USG confirmed pregnancy between 14 to 28 weeks of gestation were included in the study. A descriptive analysis was done among 100 pregnant women; they were subjected for routine investigations and clinical examination. Fasting blood samples collected from the selected pregnant women’s for lipid profile analysis. Results: The incidence of gestational hypertension in study was 34.3%. The total cholesterol ranging in the individuals tends to have the mean ranging 214.76 ± 72.25 mg/dl and these individuals have greater range of mean score of TG level 250.12 ± 66.81 followed by LDL mean score as 116.28 ± 45.55 mg/dl with the lowest range of VLDL mean scoring predicted as 36.34 ± 19.54 mg/dl. The total cholesterol, TG levels and VLDL have a significant effect on gestation hypertension in maternal period with the mean ranging as 25.32 and TG denoted as 277.69 whereas the values of HDL and LDL does not have any effect on GHTN. Conclusion: The lipid profile acts as the most promising biomarker in identifying the condition of hypertension in the pregnancy. Lipid profile analysis in early 2nd trimester is a simple noninvasive and economical for the prediction of hypertensive disorders in pregnancy.

Background: Hypertension disorders represent the most common medical complication of pregnancy. Studies state that abnormal placentation and endothelial dysfunction are the key factors in the development of pre-eclampsia. Lipid levels in the early pregnancy can be a good predictor of development of preeclampsia. Dyslipidemia in early pregnancy leads to more oxidative stress by the formation of lipid peroxidases and reactive oxygen species, thus predisposing to development of pre-eclampsia. The pathological state of hypertension at the maternal period predisposing the condition of pre-eclampsia occurs due to reduced capacity of perfusion in placenta enhance the dysfunction of vascular endothelial system which arises from lesser invasion of cytotrophoblasts into the arteries of uterus. The research aims to estimate the lipid concentration in the second trimester of pregnancy for prediction of hypertension. Materials and Methods: This study was done as a prospective cohort study at antenatal clinic, department of obstetrics and gynecology at Government Mohan Kumaramangalam medical college, Salem. Pregnant women with singleton pregnancy with LMP and USG confirmed pregnancy between 14 to 28 weeks of gestation were included in the study. A descriptive analysis was done among 100 pregnant women; they were subjected for routine investigations and clinical examination. Fasting blood samples collected from the selected pregnant women’s for lipid profile analysis. Results: The incidence of gestational hypertension in study was 34.3%. The total cholesterol ranging in the individuals tends to have the mean ranging 214.76 ± 72.25 mg/dl and these individuals have greater range of mean score of TG level 250.12 ± 66.81 followed by LDL mean score as 116.28 ± 45.55 mg/dl with the lowest range of VLDL mean scoring predicted as 36.34 ± 19.54 mg/dl. The total cholesterol, TG levels and VLDL have a significant effect on gestation hypertension in maternal period with the mean ranging as 25.32 and TG denoted as 277.69 whereas the values of HDL and LDL does not have any effect on GHTN. Conclusion: The lipid profile acts as the most promising biomarker in identifying the condition of hypertension in the pregnancy. Lipid profile analysis in early 2nd trimester is a simple noninvasive and economical for the prediction of hypertensive disorders in pregnancy.