Introduction: Pilocarpine is direct acting parasympathomimetic agent, acts on autonomic nervous system. Intra ocular pressure (IOP) is the major risk factor for the development of glaucoma. A study was conducted to find the short time effect of 2% Pilocarpine eye drops on IOP. Methods: This was a hospital based, prospective study, conducted in the department of Ophthalmology, GITAM Institute of Medical sciences & Research, Visakhapatnam. Study was conducted between January to June 2023. Individuals aged > 20 years, both gender diagnosed to be angle closure glaucoma and different subtypes were included in this research. The preprocedural IOP was recorded with goldman applanation tonometer, recorded in milli meters of mercury (mm Hg). Pilocarpine eye drops at 2% concentration was instilled to both eyes for every 30 minutes for 2 hours and IOP was measured. The data were represented in mean + SD. ANOVA test was used for the statistical analysis. P<0.05 was considered to be statistically significant. Results: Total 50 members were included, female male ratio was 2.3. Maximum (24%) study members were in 40 – 50 years group and minimum (8%) in < 20 years group. The mean + SD IOP was 17.3 + 6.2498 and 14.52 + 5.1217, respectively in pre and post administration of 2% pilocarpine eye drops; statistically there was significant difference (P = 0.001). Conclusions: Pilocarpine can bring significant IOP reduction among the glaucoma individuals. But small sample size, short duration of study and not reporting the diurnal and nocturnal data are the limitations of the study. Studies on large sample size for long time is recommended.

Introduction: Pilocarpine is direct acting parasympathomimetic agent, acts on autonomic nervous system. Intra ocular pressure (IOP) is the major risk factor for the development of glaucoma. A study was conducted to find the short time effect of 2% Pilocarpine eye drops on IOP. Methods: This was a hospital based, prospective study, conducted in the department of Ophthalmology, GITAM Institute of Medical sciences & Research, Visakhapatnam. Study was conducted between January to June 2023. Individuals aged > 20 years, both gender diagnosed to be angle closure glaucoma and different subtypes were included in this research. The preprocedural IOP was recorded with goldman applanation tonometer, recorded in milli meters of mercury (mm Hg). Pilocarpine eye drops at 2% concentration was instilled to both eyes for every 30 minutes for 2 hours and IOP was measured. The data were represented in mean + SD. ANOVA test was used for the statistical analysis. P<0.05 was considered to be statistically significant. Results: Total 50 members were included, female male ratio was 2.3. Maximum (24%) study members were in 40 – 50 years group and minimum (8%) in < 20 years group. The mean + SD IOP was 17.3 + 6.2498 and 14.52 + 5.1217, respectively in pre and post administration of 2% pilocarpine eye drops; statistically there was significant difference (P = 0.001). Conclusions: Pilocarpine can bring significant IOP reduction among the glaucoma individuals. But small sample size, short duration of study and not reporting the diurnal and nocturnal data are the limitations of the study. Studies on large sample size for long time is recommended.