This study examines the ability of personality traits to predict the quality of life and satisfaction of patients with gender identity disorder following gender reassignment surgery. The study methodology employed is descriptive-correlational, with the application of post-event research. The findings indicate that neuroticism exhibits the most predictive ability among personality traits in relation to quality of life, with extraversion and openness to experience following closely behind. Neuroticism has a negative correlation with life satisfaction, but extraversion and openness to experience have a favorable correlation with life contentment. After gender reassignment surgery, the aspects of personality known as agreeableness and conscientiousness did not contribute to explaining life satisfaction in individuals with gender identity disorder. The findings refute the third and fourth hypotheses, suggesting that there is no significant difference in the level of satisfaction with quality of life between women and men, and that there is no significant difference in the level of satisfaction with life between women and men.