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MR1-restricted T-cell clonotypes are associated with 'resistance' to Mycobacterium Tuberculosis infection - TRA/D immunoSEQ

Name: MR1-restricted T-cell clonotypes are associated with 'resistance' to Mycobacterium Tuberculosis infection - TRA/D immunoSEQ
Keywords: FOS: Clinical medicine, Immunology

Research datakeyboard_double_arrow_right Dataset 08 May 2024Publisher:Zenodo

Authors: Cross, Deborah; Seshadri, Chetan;

doi: 10.5281/zenodo.10999748 , 10.5281/zenodo.10999747

MR1-restricted T-cell clonotypes are associated with 'resistance' to Mycobacterium Tuberculosis infection - TRA/D immunoSEQ

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Abstract

Summary Number of files: 39 Data format: tsv Data type: TCRA/D immunoSEQ (Adaptive Biotechnologies) immunoSEQ version: v2 Sample type: peripheral blood mononuclear cells (PBMCs) Genomic DNA extraction protocol: QIAGEN DNeasy Blood and Tissue kit Sample description Peripheral blood samples were collected from participants enrolled in a longitudinal cohort study based in Uganda. Donors were classified as either "resistors" (RSTRs, n = 19, defined as concordantly negative for tuberculin skin test and IFNg release assay despite high environmental exposure) or latently infected with M. Tuberculosis (LTBI, n = 20, concordantly as longitudinally positive for tuberculin skin test and IFNg release assay). Genomic DNA (gDNA) was extracted from cryopreserved PBMCs without stimulation or enrichment of T-cells using the Quiagen DNeasy Blood and Tissue kit. Protocol can be found at: https://www.qiagen.com/us/products/discovery-and-translational-research/dna-rna-purification/dna-purification/genomic-dna/dneasy-blood-and-tissue-kit

Related Organizations

University of Mary
United States

Keywords

FOS: Clinical medicine, Immunology

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