This study engaged 110 participants over a period spanning from November 14 to December 16, 2021, ensuring representation across various demographic factors: 53 females, 57 males, aged 18-70, with varied annual incomes and from 17 Spanish regions. The MobileWell100+ dataset, openly accessible, encompasses a wide array of data collected via the participants' mobile phone, including demographic details, COVID-19-related inquiries, and emotional, social, behavioral, and well-being data. Complementing this, social welfare data from external sources offers contextual insight. Methodologically, the project presents a promising avenue for uncovering new social, behavioral, and emotional indicators, supplementing existing literature. Notably, artificial intelligence is considered to be instrumental in analysing these data, discerning patterns, and forecasting trends, thereby advancing our comprehension of individual and population well-being. Ethical standards were upheld, with participants providing informed consent. The following is a non-exhaustive list of collected data: Data continuously collected through the participants' smartphone sensors: physical activity (resting, walking, driving, cycling, etc.), name of detected WiFi networks, connectivity type (WiFi, mobile, none), ambient light, ambient noise, and status of the device screen (on, off, locked, unlocked). Data corresponding to an initial survey prompted via the smartphone, with information related to demographic data, symptoms and COVID vaccination, average hours of physical activity, and answers to a series of questions to measure mental health, many of them taken from internationally recognised psychological and well-being scales (PANAS, PHQ, GAD, BRS and AAQ). Data corresponding to daily surveys prompted via the smartphone, where variables related to mood (valence, activation, energy and emotional events) are measured. Data corresponding to weekly surveys prompted via the smartphone, where information on work situation, symptoms and COVID vaccination, hours of physical activity per week, questions related to physical and mental health, etc. is requested. For a more detailed description of the study please refer to MobileWell100+StudyDescription.pdf. For a more detailed description of the collected data, variables and data files please refer to MobileWell100+FilesDescription.pdf.