| The present study aimed to evaluate the interactive effect between the concentration of several pollutants metals (Zn, Cd, Mn, and Cu) detected in the soft tissue of the winged oyster Pteria colymbus and the environmental variables that occurred during the culture period. Quantification of contaminants was performed by inductively coupled plasma optical emission spectrophotometry. Monthly sampling of environmental variables in the water column included total particulate matter (TPM), organic fractions (POM) and inorganic fractions (PIM), temperature, dissolved oxygen, chlorophyll a (Chl-a), and the upwelling index. The results showed a decreasing order in the levels of Zn > Cd > Mn > Cu. The principal components analysis showed a significant and direct relationship between the upwelling index and Zn, Cd, and Cu, and an inverse and significant relationship with Mn. On the other hand, this analysis also showed an inverse and significant relationship between Zn, Cu, and Cd with the temperature (cold waters), suggesting that the source of the availability of these contaminants is not local and that it depends more on the transport of water masses caused probably by the action of upwelling. Due to the high concentration levels of Zn and Cd, the consumption of P. colymbus cannot be considered safe according to the tolerable limits of these contaminants, which exceeded the allowed levels. However, interest in the cultivation of members of the Pteriidae family does not decay due to the great benefit of their potential to produce round and mabé pearls.