Introduction: An effective pre-anaesthetic medication for use in children undergoing surgery is required to alleviate apprehension about anaesthesia and surgery, reduce trauma from separation from patents, and facilitate induction of general anaesthesia without lengthening the post-anesthesia recovery period. Aim And Objectives: The objective of comparative study between intranasal dexmedetomidine and intranasal midazolam as premedication in paediatric age group is to evaluate and compare the following effects between two groups. (1) Time of onset of sedation, (2) Duration of sedation, (3) Level of sedation, (4) Anxiolytic effect, Ease of child parent separation, (5) Side effects. Results: (1) The mean value of age with standard deviation are 6.43+1.43 Group D and 5.28+1.63 for Group M. There was no significant difference between two groups (p<0.03). (2) Study group D had 73.3% male and 26.7% female subjects whereas Group M had 58.3% male and 41.7% female subjects. No significant difference in sexwise distribution was observed between two study group. (3) Comparison of saturation of oxygen in the blood at an interval of 15,30,45 minutes respectively. Group D had mean SPO2 of 98.03+0.86 at 45 minutes interval. Whereas group 99.12+1.32 which is found to be statistically significant. (4) Mean sedation score at 15 minutes interval is 2.82+0.43 in Group D whereas in group M 4.83+0.39 (p<0.000) which is statistically highly significant. (5) Mean behavior score of 1.85+0.36 at 10 min. in group D whereas 2.87+0.34 in group M (p<0.000) which is statistically highly significant. Conclusion: Compared to midazolam, intranasal dexmedetomidine resulted in reduced sedation, easier child-parent separation, and faster postoperative recovery with no side effects. Thus, intranasal dexmedetomidine may be administered effectively and safely as a pre-anaesthetic medication in children undergoing minor surgical procedures under general anaesthesia.

Introduction: An effective pre-anaesthetic medication for use in children undergoing surgery is required to alleviate apprehension about anaesthesia and surgery, reduce trauma from separation from patents, and facilitate induction of general anaesthesia without lengthening the post-anesthesia recovery period. Aim And Objectives: The objective of comparative study between intranasal dexmedetomidine and intranasal midazolam as premedication in paediatric age group is to evaluate and compare the following effects between two groups. (1) Time of onset of sedation, (2) Duration of sedation, (3) Level of sedation, (4) Anxiolytic effect, Ease of child parent separation, (5) Side effects. Results: (1) The mean value of age with standard deviation are 6.43+1.43 Group D and 5.28+1.63 for Group M. There was no significant difference between two groups (p<0.03). (2) Study group D had 73.3% male and 26.7% female subjects whereas Group M had 58.3% male and 41.7% female subjects. No significant difference in sexwise distribution was observed between two study group. (3) Comparison of saturation of oxygen in the blood at an interval of 15,30,45 minutes respectively. Group D had mean SPO2 of 98.03+0.86 at 45 minutes interval. Whereas group 99.12+1.32 which is found to be statistically significant. (4) Mean sedation score at 15 minutes interval is 2.82+0.43 in Group D whereas in group M 4.83+0.39 (p<0.000) which is statistically highly significant. (5) Mean behavior score of 1.85+0.36 at 10 min. in group D whereas 2.87+0.34 in group M (p<0.000) which is statistically highly significant. Conclusion: Compared to midazolam, intranasal dexmedetomidine resulted in reduced sedation, easier child-parent separation, and faster postoperative recovery with no side effects. Thus, intranasal dexmedetomidine may be administered effectively and safely as a pre-anaesthetic medication in children undergoing minor surgical procedures under general anaesthesia.