Aspirin has an antiplatelet effect by inhibiting the production of thromboxane, which under normal circumstances binds with platelet molecules together to create a patch over damaged walls of blood vessels. Aspirin is also used long-term, at low doses, to prevent heart attacks, strokes, and blood clot formation in people at high risk for developing blood clots. The main undesirable side effects of aspirin are gastrointestinal ulcers, stomach bleeding, and tinnitus, especially in higher doses. So in order to minimize the side effects of aspirin in the gastric region these are coated with enteric material which causes the release of drug in intestinal region. The exposure of drug in the gastric region is almost prevented. The present study was carried out to assess the quality control parameters of three different brands of aspirin gastro resistant tablets marketed in Dindigul district. All the tablet brands were analysed for weight variation test, hardness, friability, disintegration studies and percentage drug release by in-vitro dissolution studies. Three different brands of aspirin tablets were passed the test for weight variation. The hardness of various brands of aspirin ranges from 5.5 kg/cm2 to 8.0 kg/cm2 and friability varies from 0.61 % to 0.76 %, hence found to be within the acceptable limits. They had shown the disintegration time varies from 2.15 to 2.75 minutes when placed in simulated intestinal fluid phosphate buffer at pH 6.8 and 93.4% to 96.6% of active drug was released within 1 hour in dissolution studies using acetate buffer pH4.5. Hence, it was concluded that all the tested formulations met the quality parameters of official specification and achieved optimum therapeutic efficacy.