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ZENODO
Article . 2024
License: CC BY
Data sources: ZENODO
ZENODO
Article . 2024
License: CC BY
Data sources: Datacite
ZENODO
Article . 2024
License: CC BY
Data sources: Datacite
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A Mathematical Model for the Prevention of HIV/AIDS in the Presence of Undetectable Equals Untransmittable Viral Load

A Mathematical Model for the Prevention of HIV/AIDS ....
Authors: Ogunmodimu, M.O.; Enock, E.P.; Kenyatta, A.P.; Affognon, S.B.; Onwuegbuche, F.C.;

A Mathematical Model for the Prevention of HIV/AIDS in the Presence of Undetectable Equals Untransmittable Viral Load

Abstract

Recent advancement in medicine has brought about the use of Antiretroviral Therapy (ART) treatment regime to reduce the viral load of a Human Immunodeficiency Virus (HIV) or Acquired Immune Deficiency Syndrome (AIDS) patients to an Undetectable equals Untransmittable (U=U) level. While half of HIV-positive individuals in the United States have achieved an undetectable viral load, African countries face distinct challenges, including unawareness of the possibility of attaining the U=U viral load. This paper presents a novel mathematical model for HIV/AIDS transmission in Africa, using Cape Verde as a case study, by incorporating the ART treatment, resulting in U=U. The qualitative properties of the model, including the boundedness and positivity of its solution were obtained. Local and global stability analyses of the Disease-Free Equilibrium (DFE) point of the model were performed using the next generation matrix approach and the direct Lyapunov method respectively. The result indicated that the DFE of the model is stable and the disease cannot invade the studied population. The model equations were solved through the implementation of MATLAB ODE45 algorithm andsimulations were performed to visualize the effects of the ART on attaining a U=U viral load. Values of the parameters which are highly significant to the spread and control of the disease were varied and graphs were obtained to visualize the effects of these variations on each model compartment. Results of the simulations indicate that it is possible to attain a U=U viral load in Africa if the ART treatment is followed religiously. Implementation of the findings of this research will contribute to curbing transmission and strengthening control efforts towards ending the HIV/AIDS epidemic.

Keywords

Acquired Immune Deficiency Syndrome, Undetectable Equals Untransmittable., Stability Analyses, Human Immunodeficiency Virus, Mathematical Model

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
1
Average
Average
Average
Green