In this review article, we learned about liposomes, which are one type of drug delivery system that can be used to target a specific tissue. The structure if a lipid bilayer and the cell membrane are similar, which allows liposomes to deliver drugs to the places where free drugs would not be able to enter, The other drug delivery methods include pharmacosomes, micro particles, released erythrocytes and noisome. In the middle of the 1960s, liposomes are sphere shaped vesicles made of one or more phospholipid bilayers-were first reported. They are now a highly helpful tool vesicles in reagent and reproduction in many scientific fields, such as biology, biophysics, chemistry, colloid science biochemistry and mathematics and theoretical physics ever since, liposomes are now available for purchase. Among many innovative drug delivery methods. Liposomes stand out for their sophisticated technology in delivering active molecules to the site of action. Currently multiple formulations of liposomes are being used in clinical settings .From conventional vesicles to liposomes technology research has advanced to second generation liposomes ,in which lipid modifications are used to create long circulating liposomes composition vesicle size and charge .Additionally liposomes with altered surfaces have been utilizing multiple molecules including acid and glycolipids. This paper provides an overview of scalable methods and emphasizes the advantages and disadvantages with regard to industrial application and evaluation.