The complex nature of cancer requires integration of advanced research data across nationalboundaries to enable progress in prevention of cancer and the development of optimalmedical care. The European mission board for cancer has identified access to data,knowledge and digital services across European borders vital for the cancer mission. Thegoal in EOSC4Cancer is to make cancer-related genomic, imaging, clinical, environmental andsocio-economics data accessible through the use and improvement of existing federatedand interoperable systems. These systems will provide an infrastructure to securely identify,share, process and reuse FAIR cancer data across borders. EOSC4Cancer use-cases willcover the patient journey from cancer prevention to diagnosis and treatment, laying thefoundation of data trajectories and workflows for future cancer research projects. Curatedand FAIR datasets will be essential for advanced analytics and computational methods,including machine learning, to be reproducible and robust. The complex nature of cancer requires integration of advanced research data across nationalboundaries to enable progress in prevention of cancer and the development of optimalmedical care. The European mission board for cancer has identified access to data,knowledge and digital services across European borders vital for the cancer mission. Thegoal in EOSC4Cancer is to make cancer-related genomic, imaging, clinical, environmental andsocio-economics data accessible through the use and improvement of existing federatedand interoperable systems. These systems will provide an infrastructure to securely identify,share, process and reuse FAIR cancer data across borders. EOSC4Cancer use-cases willcover the patient journey from cancer prevention to diagnosis and treatment, laying thefoundation of data trajectories and workflows for future cancer research projects. Curatedand FAIR datasets will be essential for advanced analytics and computational methods,including machine learning, to be reproducible and robust.