This study investigates the acceptance of Caesarean section (CS) among pregnant women attending antenatal care at COOUTH Amaku, Awka, Anambra State, with a focus on socio-cultural, economic, and healthcare infrastructure factors. The research employs a cross-sectional study design, applying a sample size of 267 participants determined through a formula accounting for confidence interval, level of uptake, design effect, and attrition. Inclusion criteria involve expectant mothers seeking antenatal care and newly delivered mothers still in the maternity ward. Data collection utilizes a questionnaire, pretested through a pilot study, administered via simple random and systematic sampling. Analysis employs descriptive statistics, Chi-Square test for categorical variables, and means with standard deviation for continuous variables. The study uncovers significant socio-cultural influences, emphasizing the need for culturally sensitive healthcare policies. Economic barriers are identified, necessitating interventions like subsidies or insurance schemes. Additionally, healthcare infrastructure challenges underscore the importance of investments and skilled professionals. Demographic factors exhibit nuanced influences, calling for tailored interventions, and religious and cultural influences highlight the necessity of collaborative efforts for effective health promotion. In conclusion, this research offers comprehensive insights into the intricate factors influencing CS acceptance, guiding targeted interventions for improved maternal and neonatal health outcomes in Anambra State.