Based on the resources analysis carried out in H2020 SAbyNA Task 2.1, key methods were selected and simplified to facilitate their implementation at the early stages of the innovation process. Methods and tests for data collection were selected from key parameters such as release rates, dustiness, release forms, transformation rates and exposure concentrations. From this activity, sector-specific methods that allows human and environmental release, fate and exposure data generation for the two SAbyNA targeted industrial sectors (i.e. additive manufacturing and paints) were developed or adapted and are reported in the present deliverable. The methods reported in the present deliverable D2.2 for human and environmental release, fate and exposure data generation are currently being tested on the two SAbyNA case studies in collaboration with WP7 to establish the relevance and effectiveness of SbD approaches. Provisional results were already reported as D2.9 and 2.10 and those two interim deliverables will be further elaborated by the end of the project gathering the whole experimental activities conducted along the project to assess release and exposure of nanomaterials for the two case studies.