Computer aided drug design CADD is an existing and diverse research merge and stimulate each other. Computer aided drug design CADD or in silico design in the application of computational or modelling in drug design. Various approaches to computer aided drug design are evaluated to show potential techniques in accordance with their needs. Two approaches are considered to designing of drug first one is structure-based and second one is ligand-based drug design. The recent foundations of CADD were established in the early 1970`s with the use of structural biological activity of insulin. The theoretical basis of CADD urges quantum mechanics and molecular modelling studies. It`s also based on the database searching and binding affinity on the basis of biological target. CADD biophysicists, structural biologists, prediction etc. These tools can tap in chemin formation to shorter the cycle of drug discovery, and thus made drug discovery most cost-effective. In this article, we can give an overview of the current computational drug design and their applications in the integrated rational drug development to aid in the progress of drug research. KEY WORDS: Computer aided drug design, in silico design, molecular modelling, ligand, biological target, development process