{"references": ["H. Yu, J. S. Neimat, \"The Treatment of Movement Disorders by Deep\nBrain Stimulation\", Vol. 5, 26-36, January 2008 \u252c\u00ae The American\nSociety for Experimental NeuroTherapeutics, Inc.", "D. S. Kern, R. Kumar, \"Deep Brain Stimulation\", The Neurologist \u00d4\u00c7\u00f3\nVolume 13, Number 5, September 2007.", "R. Edwards, A. Beuter, \"Parkinsonian Tremor and Simplification in\nNetwork Dynamics\" Bulletin of Mathematical Biology (1999)51,\n157_177 Article No. bulm 1998.0086", "A. H. V. Schapira, E. Bezard, J. Brotchie, F. Calon, G. L. Collingridge,\nB. Ferger, B. Hengerer, E. Hirsch, P. Jenner, N. Le Novere, J. A.\nObeso, M. A. Schwarzschild, U. Spampinate and G. Davidai.\"Novel\nPharmacological Targets the Treatment of Parkinson-s Disease\"\nNATURE REVIEWS DRUG DISCOVERY, VOLUME 5, Oct 2006,\n845", "J. L. Alberts, M.S. Vitek, \" The Persistent Effects of Unilateral Pallidal\nand Subthalamic Deep Brain Stimulation on Force Control in\nAdvanced Parkinson-s Patients\"", "M. Haeri, Y. Sarbaz, Sh. Gharibzadeh, \"Modeling the Parkinson-s\ntremor and its treatments\", Journal of Theoretical Biology 236, 311-\n322, 2005.", "P. Limousin, I. Martinez-Torres, \"Deep Brain Stimulation for\nParkinson-s Disease\" Vol. 5, 309-319, April 2008, the American\nSociety for Experimental NeuroTherapeutics,Inc.", "A. Antonini, \"New Strategies in Motor Parkinsonism\" 2007 Elsevier", "X. J. Feng, B. Greenwald, H. Rabitz, E. S. Brrown and R. Kosut. \"\nToWard Closed-Loop Optimization of Deep Brain Stimulation for\nParkinson-s Disease: Concepts and Lessons from a Computational\nModeling\" Appears in J. Neuroengineering 4 (2007) L14-L21\n[10] T. Fiegele, G. Feuchtner, F. Sohm, R. Bauer, J. V. Anton, T. Gotwald\nand et al \"Accuracy of stereotactic electrode placement in deep brain\nstimulation by intraoperative computed tomography\"., Department of\nNeurosurgery, Innsbruck Medical University, Anichstrasse 35, 6020\nInnsbruck, Austria b Department of Radiology II, Innsbruck Medical\nUniversity, Innsbruck, Austria Received 16 August 2007; received in\nrevised form 13 November 2007; accepted 3 January 2008\n[11] A. M. Kuncel, W. M. Grill, \"Selection of stimulus parameters for deep\nbrain stimulation\", Clinical Neurophysiology 115 (2004) 2431-2441\n[12] Erwin B. Montgomery Jra,_, John T. Galeb \"Mechanisms of action of\ndeep brain stimulation (DBS)\" Department of Neurology, National\nPrimate Research Center, University of Wisconsin-Madison, H6/538\nCSC, 600 Highland Ave., Madison, WI 53792, USA Department of\nNeurosurgery, Massachusetts General Hospital/Harvard Medical\nSchool, Edwards Research Building, EDR 410, 50 Blossom St.,\nBoston, MA 02114, USA\n[13] M.S. Titcombe, L. Glass, A. Beuter , \"Dynamics of Parkinsonian\ntremor during deep brain stimulation\", American Institute of Physics,\nDECEMBER 2001.\n[14] T. O. Videen, M. C. Campbell , S. D. Tabbal, M. Karimi, T. Hershey,\nJ. S. Perlmutter, \"Validation of a fiducial-based atlas localization\nmethod for deep brain stimulation contacts in the area of the\nsubthalamic nucleus\", Department of Neurology, Washington\nUniversity School of Medicine, St. Louis, MO 63110, USA\nMallinckrodt Institute of Radiology, Washington University School of\nMedicine, St. Louis, MO 63110, USA Department of Psychiatry,\nWashington University School of Medicine, St. Louis, MO 63110,\nUSA Department of Anatomy & Neurobiology, Washington University\nSchool of Medicine, St. Louis, MO 63110, USA Program in Physical\nTherapy, Washington University School of Medicine, St. Louis, MO\n63110, USA Received 7 June 2007; received in revised form 11\nOctober 2007; accepted 11 October 2007\n[15] B. Blad, L. Bertenstam, S. Rehncrona, H. Bjartmarz, A.-L. T\u00f6rnqvist,\n\"Measurement of contact impedance of electrodes used for deep brain\nstimulation\", ITBM-RBM 26 (2005) 344-346."]}

Deep Brain Stimulation or DBS is the second solution for Parkinson's Disease. Its three parameters are: frequency, pulse width and voltage. They must be optimized to achieve successful treatment. Nowadays it is done clinically by neurologists and there is not certain numerical method to detect them. The aim of this research is to introduce simulation and modeling of Parkinson's Disease treatment as a computational procedure to select optimum voltage. We recorded finger tremor signals of some Parkinsonian patients under DBS treatment at constant frequency and pulse width but variable voltages; then, we adapted a new model to fit these data. The optimum voltages obtained by data fitting results were the same as neurologists- commented voltages, which means modeling can be used as an engineering method to select optimum stimulation voltages.