This early publication of the H2020 SAbyNA project describes the targeted outcome of the project and describes the work flow to achieve it. The Description of Work (DoW) included a preliminary description of the scope of the SAbyNA GuidancePlatform (Section 2). The first months of the project have been dedicated to refine the scope of the SAbyNAGuidance Platform and structuring its expected workflow (Section 3). Several working groups have been createdthat started to develop some of the key elements of this platform, which facilitates moving away from abstractdiscussions and helps understanding the implications of different potential workflows. In addition, three existingindustrial case studies of Safe-by-design (SbD) implementation for nanomaterials were analysed with thepreliminary SAbyNA Guidance platform workflow in mind, and lessons derived from this analysis were used torefine the Platform (Section 4). Understanding the context in which the SAbyNA Guidance Platform will exist at the end of the project is critical.The expected scenario at the end of the SAbyNA project is presented by compiling information on the scope ofother available platforms/portals for SbD and risk assessment of nanomaterials (Section 5). Finally, next stepsforeseen in the development of the SAbyNA Guidance Platform are described (Section 6).