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ZENODO
Preprint . 2024
License: CC BY
Data sources: ZENODO
ZENODO
Preprint . 2024
License: CC BY
Data sources: Datacite
ZENODO
Preprint . 2024
License: CC BY
Data sources: Datacite
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Building an international and interdisciplinary community to develop immune digital twins for complex human pathologies

Authors: Immune Digital Twins Working Group;

Building an international and interdisciplinary community to develop immune digital twins for complex human pathologies

Abstract

Digital twins in medicine are computational models that represent the health state of individual patients over time, enabling optimal therapeutics and forecasting patient prognosis, representing a key technology for personalised care. Many health conditions involve the immune system as an essential component, and hence, it is crucial to include its key features across spatial and temporal scales in medical digital twins. The immune response is complex and heterogeneous across diseases and patients, and its modelling requires the collective expertise of the international clinical, immunology, and computational modelling communities. A 2023 three-week workshop on immune digital twins brought together almost 100 researchers from these communities into a consortium to promote interdisciplinary collaboration and develop a detailed roadmap for immune digital twin modelling and application to be pursued over the next two years. This paper outlines the initial progress on immune digital twins achieved during the workshop and the environment that enabled effective communication between these three communities. Future steps include developing a repository of existing computational models related to the human immune system and developing infrastructure to construct complex disease models, including immune system components.

Keywords

immune system, computational model, community effort, interdisciplinary collaboration, immune digital twin

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
1
Average
Average
Average
Green