After five years of collaborative efforts, including interactions with the European Commission, EOSC Association, ESFRI-EOSC task force, and e-Infrastructure Reflection Group (e-IRG), there is a need for a fresh articulation of the Science Clusters’ vision for the future, as reflected in this third position paper. This position paper serves as a reminder that: The Science Clusters prioritize advancing researchers’ access to data, tools, and resources for datadrivenscience. A cross-border open innovation environment for FAIR (Findable, Accessible,Interoperable and Reusable) data management and analytical services, respectful of CARE4 (CollectiveBenefits, Authority to Control, Responsibility and Ethics) principles and attentive to digital security,contributes to the sustainability of ESFRI and pan-European RIs. Synergies between Science Clustersenhance researchers' efficiency and productivity through open-science standards and services. This position paper: acknowledges the progress accomplished, updates the common work plan from 20215, expresses theScience Clusters' determination to establish thematic community-based ‘EOSC Science Cluster Nodes’,contingent upon resources and explains the potential implications on the interconnection with theEOSC EU Node and national nodes. Emphasizes adaptability of the Science Clusters to a unified vision capable of accepting different needswithin EOSC and outlines their operational role within the EOSC Federation. Demonstrates the requirement for urgent support of a targeted Science Cluster destination actionwithin Horizon Europe and future framework programmes in order to enable the operational role ofthe Science Clusters.