Cocaine is a central nervous system stimulant with an addictive potential. Despite its ban, it is abused worldwide. Cocaine can be consumed through different routes: nasal, oral, and intravenous. It has the potential to cause damage to different systems in the body including cardiovascular, respiratory, muscular, urinary and hepato-biliary systems. Multisystem damage due to cocaine intoxication is rare in clinical practice. We present the case of a young male patient presented to the emergency room after snorting cocaine and later found unresponsive at home. His diagnostic work up was significant for elevated cardiac enzymes, elevated liver enzymes, acute kidney injury, and rhabdomyolysis. Additionally, the patient was noted to have altered mental status and acute respiratory failure.