Powered by OpenAIRE graph
Found an issue? Give us feedback
image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ ZENODOarrow_drop_down
image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
ZENODO
Part of book or chapter of book . 2023
License: CC BY
Data sources: ZENODO
versions View all 1 versions
addClaim

This Research product is the result of merged Research products in OpenAIRE.

You have already added 0 works in your ORCID record related to the merged Research product.

Structure prediction and analysis of Daboia russelii venom through a computational approach

Authors: John J, Georrge; Urvi.S., Parekh; Mausami, Ashara;

Structure prediction and analysis of Daboia russelii venom through a computational approach

Abstract

Numerous animal species naturally produce chemicals to kill or incapacitate prey or defend against predators. Venom is a form of toxin secreted by an animal to cause harm to another. Numerous animal species naturally produce chemical toxins to kill or incapacitate prey or defend against predators. Toxins can be classified according to the location of the body where their effects are most seen. Four different types of venoms will act on our bodies differently. Snake venom is highly modified saliva containing zootoxins which facilitate the immobilisation and digestion of prey and defence against threats. Venoms contain over 20 different compounds, mostly proteins and polypeptides. Daboia russelii is a species of venomous snake in the family Viperidae. Common names are Russell’s Viper and Chain Viper. There is a total of 8 proteins found. Of the 8 proteins, 2 are also present in the human body. Antivenom used for the snakebite is mostly polyvalent snake antivenom. It is given to those who become ill after being bitten by an unidentified snake. It has been found that Russell’s viper venom (RVV) in the presence of lipoid cofactor, clots the plasma of haemophiliacs and proconvertin. RVV is also nephrotoxic in vitro. The analysis and prediction are done by retrieving sequences and predicting 2D and 3D structures by GOR-IV and Swiss Model, respectively. The refinement of structure is also done with the help of various tools. The quality check of structure is also done for a protein based on the Ramachandran plot. There are new perspectives for a better understanding of the venomous function and for fostering the discovery of new venom-derived drug candidates.

Keywords

poison, docking, toxin, Venom, structure prediction, Daboia russelii

  • BIP!
    Impact byBIP!
    citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    0
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Average
Powered by OpenAIRE graph
Found an issue? Give us feedback
citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
Green
Related to Research communities